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Upstream Bio UPB · USD

Health Care · US listing · 🇺🇸 United States

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3.58

+10.84%

Close of 9 Nov 2026, in USD

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Reference data, closing prices and charts across 45,000 companies, plus crypto, commodities and currencies.

Largest shareholders

As filed, so dates differ, and a group and its funds can both appear.

HolderSharesStakeChangeFiled
Fidelity Management & Research Company LLC7.3m13.46%−564.9k31 Dec 2025
OrbiMed Advisors, LLC5.7m10.54%—31 Dec 2025
Decheng Capital LLC3.1m5.82%−142.2k31 Dec 2025
Norges Bank Investment Management (NBIM)2.9m5.33%—31 Dec 2025
Enavate Sciences GP, LLC2.5m4.55%—31 Dec 2025
The Vanguard Group, Inc.2.4m4.41%−58.2k31 Dec 2025
BlackRock Institutional Trust Company, N.A.2.3m4.26%+257.4k31 Dec 2025
UBS Financial Services, Inc.1.8m3.34%+1.5m31 Dec 2025
Janus Henderson Investors1.5m2.83%+1.5m31 Dec 2025
Altshuler Shaham Ltd.1.3m2.48%−75.3k31 Dec 2025
Bain Capital Life Sciences Investors, LLC1.3m2.46%−1.1m31 Dec 2025
Omega Fund Management, LLC1.3m2.45%−30k31 Dec 2025
State Street Investment Management (US)1.3m2.44%+204.6k31 Dec 2025
VR Adviser, LLC1.2m2.16%—31 Dec 2025
Wellington Management Company, LLP894.7k1.66%−230.7k31 Dec 2025

Short interest

Shares sold short, 15 Oct 2026. US exchange data.

4.5m

-0.8% on the period before. 3.7 days to cover.

Short volume

Share of the day's trading sold short, 4 Nov 2026

14.4%

Last 60 trading days.

Failed deliveries

Shares not delivered on settlement, from the SEC

  • 31 Aug 2026704 shares
  • 25 Aug 20264,012 shares

Sources and methodology

Data on this tab
Our data supplier
Chart on the Overview
TradingView

Nothing here is investment advice. Prices can be delayed or wrong, so check with the exchange before relying on them. Data for this page. How we cover markets.