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Factbox-Major deals involving US drugmakers and biotechs over the past decade - Finance news and analysis from Global Banking & Finance Review
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Factbox-Major deals involving US drugmakers and biotechs over the past decade

Published by Global Banking & Finance Review

Posted on June 9, 2026

2 min read

· Last updated: July 7, 2026

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Factbox-Major deals involving US drugmakers and biotechs over the past decade

Overview of Major US Pharma and Biotech Acquisitions

July 7 (Reuters) - Vertex Pharmaceuticals has agreed to buy Crinetics Pharmaceuticals for about $10 billion, expanding its reach beyond blood disorders and pain into rare endocrine diseases.

The move adds to a growing list of high-profile transactions over the past decade by U.S. pharmaceutical companies to acquire promising therapies in fields ranging from oncology and neurology to rare diseases and obesity.

Below are some of the major deals involving U.S.-based pharma and biotech firms from the past decade:

Key Transactions by Year

2026: Recent High-Value Deals

Vertex Pharmaceuticals acquires Crinetics Pharmaceuticals

Year Acquirer Target Deal Description

Value

2026 Vertex Crinetics About $10 To expand its

Pharmaceuticals Pharmaceu billion portfolio in

ticals rare hormonal

diseases

Merck KGaA acquires Bio-Techne

2026 Merck KGaA Bio-Tech $11.3 To expand its

ne billion presence in

the life

sciences

market with

access to

research and

bioprocessing

tools

AbbVie acquires Apogee Therapeutics

2026 AbbVie Apogee $10.9 To expand

Therapeut billion immunology

ics pipeline

GSK acquires Nuvalent

2026 GSK Nuvalent $10.6 To expand

billion late-stage

cancer drug

pipeline

Boston Scientific acquires Penumbra

2026 Boston Penumbra $14.5 To expand

Scientific billion vascular

pipeline

2025: Strategic Expansions

Abbott acquires Exact Sciences

2025 Abbott <ABT.N> Exact up to $23 To gain

Sciences billion access to

Exact

Sciences'

cancer tests,

including

flagship

colorectal

cancer test

Cologuard 

Merck acquires Cidara Therapeutics

2025 Merck  Cidara $9.2 To gain

Therapeut billion access to

ics  Cidara's

experimental

drug for flu

prevention

Pfizer acquires Metsera

2025 Pfizer  Metsera  $10 To gain a

billion foothold in

the

fast-growing

obesity

treatment

market

Merck & Co acquires Verona Pharma

2025  Merck & Co  Verona About $10 Strengthens

Pharma  billion Merck's

respiratory

portfolio

amid looming

Keytruda

patent cliff

Johnson & Johnson acquires Intra-Cellular Therapies

2025 Johnson & Intra-Cel $14.6 Expands J&J's

Johnson  lular billion footprint in

Therapies brain disease

treatments

2024: Notable Acquisition

Novo Holdings acquires Catalent

2024 Novo Holdings Catalent  $16.5 Boosts

billion manufacturing

Key Takeaways

  • The Nuvalent deal reflects soaring M&A valuations in oncology, with GSK paying a 40 % premium and investing about US$9.4 billion net of cash acquired (investing.com).
  • Recent years have seen record-setting transactions—from Abbott's potential US$23 billion deal for Exact Sciences in 2025 to Bristol‑Myers Squibb’s US$74 billion acquisition of Celgene in 2019 (sahmcapital.com).
  • These deals reveal pharma giants’ strategies to fill pipeline gaps across oncology, rare diseases, obesity, and diagnostics amid patent expiries and competition (investing.com)

References

Frequently Asked Questions

What was the biggest US pharma deal in the past decade?
The largest deal was Bristol Myers Squibb's $74 billion acquisition of Celgene Corp in 2019.
Why are US drugmakers acquiring biotech firms?
US drugmakers acquire biotech firms to expand their drug pipelines, gain access to promising therapies, and strengthen portfolios in oncology, rare diseases, and other growth areas.
Which recent deals focus on obesity and cancer treatments?
Pfizer acquired Metsera for $10 billion for obesity treatments and GSK agreed to buy Nuvalent for $10.6 billion to bolster its cancer drug pipeline.
How have pharma mergers impacted the rare disease treatment sector?
Mergers like Amgen's $27.8 billion purchase of Horizon Therapeutics have fortified rare disease portfolios for acquirers.

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