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Factbox-Major deals involving US drugmakers and biotechs over the past decade

Published by Global Banking & Finance Review

Posted on June 9, 2026

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· Last updated: June 9, 2026

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Major US Drugmaker and Biotech Transactions Over the Past Decade

Overview of High-Profile Pharma and Biotech Deals

June 9 (Reuters) - GSK has agreed to buy cancer drug developer Nuvalent for $10.6 billion in its biggest deal in years, as the British drugmaker looks to bolster its pipeline and support long-term revenue growth.

The move adds to a growing list of high-profile transactions over the past decade by U.S. pharmaceutical companies to acquire promising therapies in fields ranging from oncology, neurology to rare diseases and obesity.

Below are some of the major deals involving U.S.-based pharma and biotech firms from the past decade

Major Transactions by Year

2026 Deals

GSK Acquires Nuvalent

Year Acquirer Target Deal Description

Value

2026 GSK Nuvalent $10.6 To expand

billion late-stage

cancer drug

pipeline

Boston Scientific Acquires Penumbra

2026 Boston Penumbra $14.5 To expand

Scientific billion vascular

pipeline

2025 Deals

Abbott Acquires Exact Sciences

2025 Abbott Exact up to $23 To gain

<ABT.N> Sciences billion access to

Exact

Sciences'

cancer tests,

including

flagship

colorectal

cancer test

Cologuard 

Merck Acquires Cidara Therapeutics

2025 Merck  Cidara $9.2 To gain

Therapeut billion access to

ics  Cidara's

experimental

drug for flu

prevention

Pfizer Acquires Metsera

2025 Pfizer  Metsera  $10 To gain a

billion foothold in

the

fast-growing

obesity

treatment

market

Merck & Co Acquires Verona Pharma

2025  Merck & Verona About $10 Strengthens

Co  Pharma  billion Merck's

respiratory

portfolio

amid looming

Keytruda

patent cliff

Johnson & Johnson Acquires Intra-Cellular Therapies

2025 Johnson & Intra-Cel $14.6 Expands J&J's

Johnson  lular billion footprint in

Therapies brain disease

treatments

2024 Deals

Novo Holdings Acquires Catalent

2024 Novo Catalent  $16.5 Boosts

Holdings billion manufacturing

(includin capacity for

g debt), Novo

$11.5 Nordisk's

billion popular

(excludin obesity drug

g debt) Wegovy

2023 Deals

Merck & Co Acquires Prometheus Biosciences

2023 Merck & Prometheu $10.8 Adds

Co  s billion experimental

Bioscienc treatment for

es ulcerative

colitis and

Crohn's

disease and

builds up

presence in

immunology

Bristol Myers Squibb Acquires Karuna Therapeutics

2023 Bristol Karuna $14 BMY gains a

Myers Therapeut billion promising

Squibb ics antipsychotic

medicine as

Key Takeaways

  • The Nuvalent deal reflects soaring M&A valuations in oncology, with GSK paying a 40 % premium and investing about US$9.4 billion net of cash acquired (investing.com).
  • Recent years have seen record-setting transactions—from Abbott's potential US$23 billion deal for Exact Sciences in 2025 to Bristol‑Myers Squibb’s US$74 billion acquisition of Celgene in 2019 (sahmcapital.com).
  • These deals reveal pharma giants’ strategies to fill pipeline gaps across oncology, rare diseases, obesity, and diagnostics amid patent expiries and competition (investing.com)

References

Frequently Asked Questions

What was the biggest US pharma deal in the past decade?
The largest deal was Bristol Myers Squibb's $74 billion acquisition of Celgene Corp in 2019.
Why are US drugmakers acquiring biotech firms?
US drugmakers acquire biotech firms to expand their drug pipelines, gain access to promising therapies, and strengthen portfolios in oncology, rare diseases, and other growth areas.
Which recent deals focus on obesity and cancer treatments?
Pfizer acquired Metsera for $10 billion for obesity treatments and GSK agreed to buy Nuvalent for $10.6 billion to bolster its cancer drug pipeline.
How have pharma mergers impacted the rare disease treatment sector?
Mergers like Amgen's $27.8 billion purchase of Horizon Therapeutics have fortified rare disease portfolios for acquirers.

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