Published by Global Banking & Finance Review®
Posted on January 17, 2026
3 min readLast updated: January 19, 2026
Add as preferred source on GoogleEuropean research confirms paracetamol is safe during pregnancy, countering claims of a link to autism. The study analyzed data from over 260,000 children.
By Jennifer Rigby
LONDON, Jan 17 (Reuters) - Taking paracetamol, known as Tylenol in the U.S., during pregnancy is safe, a group of European researchers have said, after compiling data in response to U.S. President Donald Trump’s claims of a link to autism last year.
In a review published in the British journal The Lancet Obstetrics, Gynaecology & Women’s Health on Saturday, the team said they had focused on amassing the best-quality evidence to address the claims.
“Paracetamol is safe to use in pregnancy,” said lead author Asma Khalil, professor of obstetrics and maternal foetal medicine at City St George’s, University of London.
“The key message is reassurance: When used as recommended, the best available evidence does not support a causal link with autism, ADHD (attention-deficit/hyperactivity disorder) or intellectual disability.”
TYLENOL NOT LINKED TO AUTISM OR ADHD
Khalil said she had been asked about the popular pain medication – also known as acetaminophen – by her patients after Trump in September told pregnant women not to take the drug. At the time, national and international medical groups decried the president’s comments, saying they were not evidence-based.
A spokesperson for the U.S. Department of Health and Human Services said in response that "many experts have expressed concern of the use of acetaminophen during pregnancy."
Recent studies have yielded conflicting conclusions on whether its use during pregnancy might create risks for a developing fetus. A 2024 study in Sweden found no causal link to disorders such as autism, while a 2025 review by U.S. researchers said there was a suggestion of a link. They advised that pregnant women should continue to use acetaminophen as needed, at the lowest possible dose and for the shortest possible period.
Paracetamol/Tylenol is the only pain reliever considered safe for pregnant women, and doctors already advise them to use it with caution. Untreated, these conditions can be risky for both pregnant women and their babies.
The European researchers conducted a systematic review and meta-analysis of existing data, finding 43 studies that were then assessed for quality and bias using a standard tool.
The team particularly focused on studies that looked at children born to the same mother who took paracetamol/Tylenol during one pregnancy but not the other. These take into account shared genetic factors and family environments that could be linked to autism or the other conditions studied, Khalil said.
There were only three studies of this type, but they were large, covering more than 260,000 children assessed for autism, and around 335,000 and 405,000 for ADHD and intellectual disabilities respectively.
ACCOUNTING FOR BIAS
They showed no significant link between use of the drug and any of the conditions studied. This remained the case when results from all of the high-quality studies that were assessed were pooled, the authors said.
Khalil said much of the work showing a potential link, including the 2025 review of 46 studies cited by Trump officials, was prone to bias or confounding factors that her team's review had tried to account for.
Grainne McAlonan, professor of Translational Neuroscience at King's College London, who was not involved in the research, praised the study, adding: “I hope the findings of this study bring the matter to a close.”
(Reporting by Jennifer Rigby; Editing by Kevin Liffey and Franklin Paul)
Paracetamol, also known as acetaminophen, is a common pain reliever and fever reducer used to treat various conditions, including headaches, muscle aches, and colds.
Autism is a developmental disorder characterized by challenges with social skills, repetitive behaviors, and communication. It affects individuals differently and to varying degrees.
Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder marked by inattention, hyperactivity, and impulsivity, which can affect daily functioning and development.
Intellectual disability is a condition characterized by limitations in intellectual functioning and adaptive behavior, impacting everyday social and practical skills.
A systematic review is a research method that collects and critically analyzes multiple research studies or papers on a specific topic, aiming to provide a comprehensive understanding of the evidence.
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