Published by Coherent Market Insights
Posted on September 20, 2021
5 min readLast updated: February 4, 2026
The freeze drying equipment market is set to grow significantly, reaching $68,817.1 million by 2027, driven by the demand for biologics and biopharmaceutical R&D.
Lyophilization/Freeze Drying Equipment Market – Powerful Components of Drug Development & Research
Freeze drying is removal of ice or other frozen solvents from a material through the process of sublimation and removal of bound water molecules through the process of desorption. It is an excellent method of preserving a wide variety of heat-sensitive materials such as proteins, microbes, pharmaceuticals, tissues, and plasma. Lyophilization has also application in biotechnology and biomedical industries to preserve vaccines, blood samples, purified proteins, and other biological material. This process is an efficient technique for preservation of temperature sensitive and biologic products such as proteins, enzymes, blood plasma, and vaccines.
The global lyophilization/freeze drying equipment market was valued at US$ 2,116.5 million in 2017, and is expected to exhibit a CAGR of 6.5% over the forecast period (2018-2026).
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Increasing biopharmaceutical production with extensive R&D is expected to drive growth of the market
Increasing drug development process and biopharmaceutical research are major factors that are expected to augment growth of the market, as lyophilization is majorly adopted in pharmaceuticals/ biopharmaceuticals to improve stability, thereby achieve adequate shelf life. Lyophilization or freeze-drying is vital process in developing and manufacturing unstable and sensitive pharmaceuticals, as they aid in introducing new pharmaceutical to market. Biopharmaceuticals are manufactured by using genetically modified organisms and temperature sensitive complex molecules, which require gentle freeze drying with the lyophilisation process to attain adequate shelf life. According to the survey by Martin Christ GmbH, around 60% of the biopharmaceutical products, such as special cancer treatment substances and antibodies require freeze drying for attaining efficient results in clinical trials. Moreover, increasing number of global biopharmaceutical companies is expected to boost market growth over the forecast period as these companies are highly dependent on lyophilization due to wide availability of biologics, which include vaccines, blood components, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins. According to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, biopharmaceutical companies are focused on developing drugs for treatment of diseases such as cancers which has 1,919 medicines in development, 563 medicines for cardiovascular diseases, and 1,123 medicines for immunological disorders, which require recombinant proteins for various stages for drug development. Furthermore, according to the Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, member companies invested around US$ 58.8 billion in research and development in 2015, which was majority of all biopharmaceutical R&D spending in the U.S.
Moreover, according to the survey by Future Science Group, 2016, injectable products are majorly selected as formulations for new therapeutics. However, liquid formulations often enhances degradation through hydrolysis. Thus, lyophilization/ freeze-drying is regularly used in pharmaceutical manufacture to reduce water activity and assures product stability.
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The lab-scale freeze dryers are used in R&D prior to a scale up, as moving a new product to commercial-scale manufacturing requires careful validation. Demonstrating batch uniformity is an essential part of this critical process. Moreover, freeze-drying has created novel opportunities in the area of oral drug delivery, wherein properties of the drugs, excipients, and characteristics of the final solid dosage form can be modified by the freeze-drying process. Asia Pacific region is estimated to witness significant growth in the market, owing to increasing number of research laboratories and pharmaceutical companies with increased expenditure on research and development in this region. For instance, according to the National Bureau of Statistics, February 2018, China’s expenditure on research and development increased by 11.6% in 2017 from 10.6% in 2016, reaching to US$ 280 Bn in 2017. For instance, according to the International Journal of Sciences, January 2018, China’s biotechnology sector is expected to exceed by 4% of gross domestic product by 2020, and is expected to develop around 10-20 life-science parks for biomedicine with an output surpassing US$ 1.5 billion.
Major players operating in the global lyophilization/freeze drying equipment market include Thermo Fisher Scientific, Inc., Millrock Technology Inc., Zirbus Technology GmbH, SP Scientific, Azbil Telstar, S.L., Biopharma Process Systems Ltd., LTE Scientific Ltd., Martin Christ GmbH, GEA Group, and Cuddon Freeze Dry.
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The post Freeze Drying Equipment Market Size & Trends 2020 – expected to reach US$ 68,817.1 Million With a CAGR of 10.5% by 2027, Owing to Increasing demand for biologics appeared first on Gatorledger.
The article discusses the growth and trends in the freeze drying equipment market, particularly in relation to biopharmaceuticals.
Freeze drying is essential for preserving heat-sensitive materials like biologics, ensuring stability and shelf life.
The market growth is driven by increasing biopharmaceutical production and research and development activities.
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