Published by Jessica Weisman-Pitts
Posted on April 8, 2025
Oligonucleotide Synthesis with High Precise and Yield Driving Demand for Custom Oligos: Fact.MR Analysis
The global oligonucleotide synthesis market size is projected to jump from US$ 6.76 billion in 2024 to US$ 19.01 billion by 2034, mainly due to the rising demand for customized nucleotides for application in research, genetic testing, forensics, and drug development. This has been revealed by Fact.MR, a market research and competitive intelligence provider, in its recently updated market report.
Oligonucleotide therapeutics is gaining traction due to its effective results in the treatment of chronic diseases such as cancers, cardiovascular disorders, and retinal disorders. The integration of advanced technologies such as Clustered Regularly Interspaced Short Palindromic Repeats) CRISPR genome editing technology is set to boost overall market growth.
The availability of positive regulatory support is also driving the oligonucleotide synthesis demand. The ongoing evolution in the regulatory framework to support a well-framed environment for advanced research is set to increase the sales of oligonucleotide synthesis solutions. Synthetic biology, genetic engineering, stem cells, and regenerative medicine are some of the high potential fields in healthcare.
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Key Takeaways from the Market Study:
“Oligo sequences are expected to exhibit increasing applications in various fields of biotechnology due ongoing developments in R&D,” says a Fact.MR analyst.
Competitive Analysis
North America and Europe, being big regions, are offering lucrative opportunities for oligonucleotide synthesis market players. The presence of advanced healthcare infrastructure, as well as the biotech sector, is aiding the market growth in these regions.
The oligonucleotide synthesis market is characterized by the presence of both established companies as well as start-ups. Rapid advancements in gene editing technology are set to boost the profits of oligonucleotide synthesis producers.
High Costs and Complexity of Oligonucleotide Synthesis
The use of synthetic oligonucleotides as therapeutic drugs for disease treatment has grown significantly over the past decade. However, the market faces challenges due to high costs and potential severe side effects, which have led to the discontinuation or failure of several drugs during clinical trials. If such issues persist, they could hinder market expansion. Additionally, the intricate nature of oligonucleotide synthesis presents further obstacles that may limit overall market growth.
Expanding Revenue Opportunities for Oligonucleotide Synthesis Producers
German companies are prioritizing the development of more efficient and eco-friendly oligonucleotide synthesis processes. The demand for oligonucleotides is rising across diverse applications, including research, therapeutics, drug discovery, forensics, and agriculture. In Germany, their use is also increasing in forensic and biological fields as sequence-specific binding agents, further driving market growth.
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Key Market Players:
More Valuable Insights on Offer
Fact.MR, in its new offering, presents an unbiased analysis of the global oligonucleotide synthesis market, presenting historical demand data (2018 to 2023) and forecast statistics for the period (2024 to 2034).
The study divulges essential insights on the market based on product (reagents & consumables, equipment, synthesized oligonucleotides, others), application (research, therapeutics, diagnostics), and end user (biotechnology & pharmaceutical companies, research institutes, diagnostic laboratories), across six major regions of the world (North America, Latin America, Europe, East Asia, South Asia & Oceania, and MEA).
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