Finance
Novartis flags 2026 profit drop as patents for key drugs expire
Published by Global Banking & Finance Review®
Posted on February 4, 2026
3 min readLast updated: February 4, 2026
Global Banking & Finance Review®
Company
Published by Global Banking & Finance Review®
Posted on February 4, 2026
3 min readLast updated: February 4, 2026
Novartis forecasts a low single-digit decline in 2026 operating profit due to competition from cheaper generic drugs like Entresto.
By Ludwig Burger and Bhanvi Satija
FRANKFURT, Feb 4 (Reuters) - Novartis forecast its first annual drop in operating profit in a decade on Wednesday, even as it indicated that long term, the company could potentially offset the patent expiry of its established products, such as heart drug Entresto.
The Swiss drugmaker said 2026 operating profit, adjusted for one-offs, would slip by a low single-digit percentage, excluding currency swings. The last such decline was in 2016, which took the spin-off or sale of businesses into account.
Novartis is leaning on cancer drugs Kisqali and Scemblix and last year's $30 billion spent on deals, to offset patent expiries, spelling the loss of market exclusivity, on blockbuster drugs like Entresto for heart failure and allergy treatment Xolair.
The 2026 guidance on Wednesday included a projection for low single-digit gains in group sales, without mentioning numbers.
That compares with an analyst consensus by Visual Alpha for a revenue gain of about 6.6% to $58.2 billion this year.
Analysts at Jefferies said the lower part of the company's implied 2026 profit guidance range of $21.3-$22 billion, assuming a 1% foreign-exchange tailwind, could spur analysts to trim estimates, which had been at $21.8 billion on average.
Novartis shares were down 1.8% at 0957 to a two-day low.
COMPANY OPTIMISTIC OF HITTING MID-TERM GOALS
CEO Vas Narasimhan, however, was optimistic of hitting mid-term targets, stressing longer-term growth prospects and projecting sales growth this year despite competition from generic drugmakers.
"In 2026, we expect to grow through the largest patent expiry in Novartis history, underscoring the strength of our business, and remain well on track to deliver our mid-term guidance," he said.
The CEO, at the helm for eight years, had a 24.9 million Swiss franc ($32.08 million) compensation package for 2025, up 30%, driven by a three-year share price performance of 64%, according to the annual report.
Mukul Mehta, set to become CFO in March, told Reuters that adjusted operating income "really starts to grow in the second half of the year, which bodes very well for 2026 second half and 2027 and beyond."
Novartis reported a 1% gain in fourth-quarter operating profit to $4.92 billion, in line with market expectations, on higher sales of breast cancer drug Kisqali, multiple sclerosis drug Kesimpta and psoriasis drug Cosentyx, among others.
($1 = 0.7761 Swiss francs)
(Reporting by Ludwig Burger and Patricia Weiss in Frankfurt, Bhanvi Satija in London; Editing by Emelia Sithole-Matarise, Linda Pasquini and Bernadette Baum)
Operating profit is the amount of money a company makes from its core business operations, excluding deductions of interest and taxes. It reflects the efficiency of the company's operations.
Established products are goods or services that have been in the market for a significant period and have a stable customer base. They often face competition from newer, cheaper alternatives.
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