Published by Jessica Weisman-Pitts
Posted on November 9, 2021
4 min readLast updated: January 28, 2026
Microneedle arrays offer a minimally invasive drug delivery method, gaining popularity for their versatility and cost-effectiveness.
Billions of injections are administered worldwide on an annual basis. Nonetheless, the conventional approach via hypodermic needles is problematic due to risks involved with needle injuries, pain perception, and skin transport barrier limits. Intended as a minimally invasive and painless system, microneedle arrays (MNA) are an ideal solution for the transdermal delivery of drugs. Its ability to bypass the stratum corneum makes it a superior alternative to subcutaneous injections or other types of transdermal delivery systems such as chemical enhancers or microparticles. The primary objective of microneedles is to penetrate the skin with microscopic holes and disrupt the stratum corneum.
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Microneedles Minimize Patient Trypanophobia Aiding Immunisation Programmes
Microneedle drug delivery offers several advantages including faster onset, improved efficacy, and higher patient compliance. Microneedles provide therapeutic advantages and deliver reproducible results with pinpoint accuracy and minimal variability in bioavailability. As a painless mechanism for drug delivery, microneedles aid in overcoming trypanophobia that is the fear of needles increasing adoption rates in the paediatrics segment and boosting mass immunisation programmes. Drug delivery can be controlled with higher efficiency than other transdermal drug delivery methods.
Microneedle Companies Sharing IP With Vaccine Manufacturers to Guarantee Success
NanoPass Technologies, a key player in the microneedle drug delivery market, has decided to collaborate with immunotherapy companies to use its proprietary MicronJet assisting their efforts in creating an affordable, effective, and safe COVID-19 vaccine. Other companies involved in the microneedle drug deliver market are 3M, Microdermics, Zosano Pharma Corporation (ZSAN), Nitto Denko Corporation, Becton, Dickinson and Company, Vaxxas Pty Ltd, Valeritas (Zealand Pharma A/S), Corium, Inc., TheraJect, Inc., LTS Lohmann Therapie-Systeme AG, and Alza Corporation.
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Versatility of Microneedle Arrays Makes Them Perfect For Oral and Buccal Drug Delivery
There has been significant demand for therapies where active substances are not properly absorbed through oral administration. In addition, newer nanoparticle and microparticle drug encapsulation technologies have been invented with the number of registered patents growing by leaps and bounds. Transdermal administration shows immense promise with ovalbumin the most common protein antigen for immunisation studies with microneedle arrays. In the 21st century, cosmetics undergo maximum clinical trials with microneedle arrays and there has been rising interest for microneedles in diagnostics. Microneedle arrays can massively impact the wearable epidermal diagnostic device segment as a result of their unique attributes. Microneedle array transdermal drug delivery and patient preference for minimally invasive procedures opens up limitless opportunities for rectal, oral, ocular, and buccal drug delivery.
Low Manufacturing Cost Enables Hollow Microneedle Array Segment to Remain Popular
There are four types of fabrication available in the microneedle drug delivery market – dissolving, hollow, hydrogel, and solid microneedle arrays. Solid microneedles are manufactured from silicon or metal, are time-tested, and have a longer product lifespan. However, there has been a notable uptick in polymer microneedle arrays in the last five years. Hollow microneedle arrays usually deliver a better API quality than all other options in the microneedle drug delivery market. Furthermore, precise drug control, low cost and ease of manufacturing all work in favour of hollow microneedle arrays making them a popular choice in the microneedle drug delivery market.
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The article discusses the microneedle drug delivery market, focusing on polymer microneedle arrays and their benefits.
How do microneedles help with patient compliance? They offer a painless alternative to traditional needles, reducing fear and increasing adoption.
What are the advantages of hollow microneedles? They provide precise drug control and are cost-effective to manufacture.
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