Published by Global Banking & Finance Review®
Posted on April 12, 2026
2 min readLast updated: April 12, 2026
Add as preferred source on GoogleGSK’s experimental ADC Mo‑rez shows strong early efficacy—62% tumor shrinkage in platinum‑resistant ovarian cancer and 67% in endometrial cancer—prompting the company to call it a “blockbuster” asset and accelerating its oncology push.
By Bhanvi Satija
LONDON, April 12 (Reuters) - British drugmaker GSK's experimental targeted cancer drug Mo-rez has blockbuster potential, its head of oncology research has told reporters, after early data showed the drug helped shrink tumors in patients with advanced, hard-to-treat cancers.
"This is one of our priority assets at this stage," GSK's Hesham Abdullah said on a call with journalists discussing the early data, which is being presented at a medical conference in Puerto Rico on Sunday.
"Do we think it would be a blockbuster? Yes, absolutely," GSK's Hesham Abdullah said on the call.
Initial results measured the proportion of patients who achieved a meaningful reduction in tumor size, defined as at least a 30% shrinkage. In platinum-resistant ovarian cancer, 62% of patients met that threshold, while 67% did so in endometrial cancer.
DATA GIVE MOMENTUM TO GSK'S ONCOLOGY BUSINESS
Analysts have not yet projected future sales for mo-rez given early trial data.
The data give momentum to GSK's fast-growing oncology business. CEO Luke Miels, who started in the role in January, has said the company will speed up work on new medicines, a shift Abdullah said is already being reflected in its product development.
"I think it has been reflected in the type of pace that you are seeing and the type of conviction that we have in our programmes moving forward," he added.
GSK is testing Mo-rez in two late-stage trials in ovarian and endometrial cancers and plans to start three additional studies in coming months.
Mo-rez, an antibody‑drug conjugate, targets the B7H4 protein found on gynaecological cancer cells but is largely absent from healthy tissue. The market for ADC treatments is projected to reach $31 billion by 2030.
GSK licensed the drug from China's Hansoh Pharma in 2023.
(Reporting by Bhanvi Satija; Editing by David Holmes)
Mo-rez is an experimental targeted cancer therapy developed by GSK, shown to help shrink tumors in advanced, hard-to-treat cancers.
Mo-rez is currently being tested in late-stage trials for ovarian and endometrial cancers.
Initial data shows tumor reduction in 62% of platinum-resistant ovarian cancer patients and 67% in endometrial cancer.
Early positive trial results and large market projections for antibody-drug conjugates position Mo-rez as a potential blockbuster therapy.
GSK licensed Mo-rez from China's Hansoh Pharma in 2023.
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