By Nidal al-Mughrabi

CAIRO (Reuters) -Israeli gunfire and airstrikes killed at least 60 Palestinians in Gaza on Wednesday, most of them near an aid site operated by the U.S- and Israeli-backed Gaza Humanitarian Foundation in the centre of the enclave, local health officials said.

Medical officials at Shifa and Al-Quds hospitals said at least 25 people were killed and dozens wounded as they approached a food distribution centre near the former Jewish settlement of Netzarim before dawn.

Israel's military, which has been at war with Hamas militants since October 2023, said its forces fired warning shots overnight towards a group of suspects as they posed a threat to troops in the area of the Netzarim Corridor.

"This is despite warnings that the area is an active combat zone. The IDF is aware of reports regarding individuals injured; the details are under review," it said.

Later on Wednesday, health officials at Nasser Hospital in Khan Younis in the southern Gaza Strip said at least 14 people had been killed by Israeli gunfire as they approached another GHF site in Rafah.

The foundation said it was unaware of Wednesday's incidents but added that it was working closely with Israeli authorities to ensure safe passage routes are maintained, and that it was essential for Palestinians to closely follow instructions.

"Ultimately, the solution is more aid, which will create more certainty and less urgency among the population," it said by email in response to Reuters questions.

"There is not yet enough food to feed everyone in need in Gaza. Our current focus is to feed as many people as is safely possible within the constraints of a highly volatile environment."

In a statement, GHF said it distributed 2.5 million meals on Wednesday, the largest single-day delivery since it began operations, bringing to more than 16 million the number of meals provided since its operations started in late May.

Gaza's Hamas-run health ministry says that since then, 163 Palestinians had been killed and over 1,000 wounded trying to obtain the food boxes.

The United Nations has condemned the killings and has refused to supply aid via the foundation, which uses private contractors with Israeli military backup in what they say is a breach of humanitarian standards.

Elsewhere in Gaza on Wednesday, its health ministry said at least 11 other people were killed by separate Israeli gunfire and strikes across the coastal enclave.

The war erupted 20 months ago after Hamas-led militants took 251 hostages and killed 1,200 people, most of them civilians, on October 7, 2023, Israel's single deadliest day.

Israel's military campaign has since killed nearly 55,000 Palestinians, most of them civilians, according to health authorities in Gaza, and flattened much of the densely populated strip, which is home to more than two million people. Most of the population is displaced and malnutrition is widespread.

Israeli Prime Minister Benjamin Netanyahu said on Tuesday there had been "significant progress" in efforts to secure the release of the remaining hostages in Gaza, but that it was "too soon" to raise hopes that a deal would be reached.

Two Hamas sources told Reuters they did not know about any breakthrough in negotiations.

(Reporting by Nidal al-Mughrabi. Additional reporting by Alex Cornwell and Crispian Balmer; editing by Michael Perry, Philippa Fletcher and Mark Heinrich)