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Simulations Plus Releases ADMET Predictor® Version 9.5

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Simulations Plus, Inc. (Nasdaq:SLP), the leading provider of modeling and simulation solutions for the pharmaceutical, biotechnology, chemicals, and consumer goods industries, today announced that it has released version 9.5 of its flagship machine learning modeling platform, ADMET Predictor.

Key improvements include:

  • Novel approaches to calculate uncertainty estimates on all regression models
  • New machine learning models for important metabolism and transporter endpoints
  • New machine learning models for AMES mutagenicity, a primary toxicity endpoint required during risk assessment
  • New Structure Sensitivity Analysis visualization tool to easily map atom-level contributions to model predictions
  • Improved rat-specific models to more accurately inform HTPK Simulation predictions
  • Improved Pipeline Pilot and KNIME components to extend deployment options and enterprise support for ADMET Predictor
  • Updates to output displays in MedChem Designer„¢
  • And more¦

Dr. David Miller, director of ADMET cheminformatics, said: Our team of talented scientists and software engineers introduced a significant amount of innovative functionality, not available in other software, in this release of ADMET Predictor. In particular, the ability of chemists to now ˜see how a molecule could be optimized for important ADMET properties tells a story that can be easily communicated across departments as research programs progress. This further establishes our machine learning platform as an industry leader and will be welcomed by clients.

Lancaster division president, John DiBella, added: We continue to realize solid growth in the number of companies, from small to large, and regulatory agencies that license ADMET Predictor. Our best-in-class machine learning methods are now being applied to more enzyme and transporter isoforms, which, when paired with our physiologically-based pharmacokinetic models in GastroPlus, provide holistic insights to support discovery research efforts. We are excited to demonstrate these new features in version 9.5 and, coupled with recent investments in marketing and sales, expect to see accelerated expansion of the client base.

About Simulations Plus, Inc.

Simulations Plus, Inc., is a premier developer of drug discovery and development software as well as a leading provider of both preclinical and clinical pharmacometric consulting services for regulatory submissions and quantitative systems pharmacology models for drug-induced liver injury, drug-induced kidney injury, and nonalcoholic fatty liver disease. The company is a global leader focused on improving the ways scientists use knowledge and data to predict the properties and outcomes of pharmaceutical, biotechnology, and chemical agents. Our software is licensed to and used in the conduct of drug research by major pharmaceutical, biotechnology, chemical, and consumer goods companies and regulatory agencies worldwide. Our innovations in integrating new and existing science in medicinal chemistry, computational chemistry, pharmaceutical science, biology, and physiology into our software have made us the leading software provider for physiologically based pharmacokinetic modeling and simulation. For more information, visit our website at www.simulations-plus.com.

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995 “ With the exception of historical information, the matters discussed in this press release are forward-looking statements that involve a number of risks and uncertainties. Words like believe, expect and anticipate mean that these are our best estimates as of this writing, but that there can be no assurances that expected or anticipated results or events will actually take place, so our actual future results could differ significantly from those statements. Factors that could cause or contribute to such differences include, but are not limited to: our ability to maintain our competitive advantages, acceptance of new software and improved versions of our existing software by our customers, the general economics of the pharmaceutical industry, our ability to finance growth, our ability to continue to attract and retain highly qualified technical staff, our ability to identify and close acquisitions on terms favorable to the Company, and a sustainable market. Further information on our risk factors is contained in our quarterly and annual reports and filed with the U.S. Securities and Exchange Commission.

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Ms.
Renee Bouche
661-723-7723
[email protected]

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Mr. Cameron Donahue
651-653-1854
[email protected]

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Fraport Traffic Figures 2020: Passenger Numbers Fall to Historic Low Due to the Covid-19 Pandemic

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Massive passenger slump recorded at Frankfurt Airport and Fraport's Group airports worldwide – Relatively low decline in FRA's cargo volumes  

FRANKFURT, Germany, Jan. 18, 2021 /PRNewswire/ — FRA/gk-rap – Frankfurt Airport (FRA) welcomed some 18.8 million passengers in 2020, representing a decrease of 73.4 percent compared to 2019. With the outbreak of the Covid-19 global pandemic, Frankfurt Airport started to experience a major decline in passenger traffic in mid-March 2020. Between April and June, traffic almost came to a complete standstill – with weekly passenger figures plummeting by up to 98 percent year-on-year. Following a slight traffic recovery in the third quarter of 2020, a new rise in coronavirus infection rates led to intensified travel restrictions. This resulted in passenger numbers falling sharply once again in September and remaining low for the rest of the year. 

Fraport AG's executive board chairman, Dr. Stefan Schulte, commented: “The year 2020 brought extreme challenges to the entire aviation industry. In Frankfurt, passenger volumes dropped to a level last seen in 1984. Cargo traffic was one of the few bright spots, reaching almost the same level as in 2019 – despite the loss of “belly freight” capacity on passenger aircraft. Aviation played a vital role in ensuring the supply of essential medical goods to the world's population, particularly during the first lockdown.”

Aircraft movements at Frankfurt Airport contracted by 58.7 percent year-on-year to 212,235 takeoffs and landings in 2020. Accumulated maximum takeoff weights (MTOWs) shrank by 53.3 percent to about 14.9 million metric tons. In comparison, cargo throughput (airfreight + airmail) registered a relatively minor dip of only 8.3 percent year-on-year to just under 2.0 million metric tons.

In December 2020, FRA's passenger traffic slumped by 81.7 percent to 891,925 travelers. With 13,627 takeoffs and landings, aircraft movements declined by 62.8 percent compared to December 2019. MTOWs were down 53.6 percent to about 1.1 million metric tons. Cargo throughput grew by 9.0 percent to 185,687 metric tons in December 2020, rising for the third consecutive month.

Looking forward, CEO Schulte said: “Because of the recent launch of vaccination programs throughout many countries, we are optimistic that travel restrictions will be gradually lifted beginning in the spring.  Therefore, we expect Frankfurt's passenger traffic to rebound noticeably in the second half of 2021. Nevertheless, we have to realize that a difficult year lies ahead of us. While we are confident passenger traffic will exceed last year's level, we still expect Frankfurt to reach only 35 to 45 percent of the 2019 level.”

Fraport's international portfolio also hit by sharp traffic declines  

Across the Group, the airports in Fraport's international portfolio also recorded a sharp decline in passenger traffic during 2020. However, the Covid-19 pandemic impacted the individual Group airports to varying degrees over the months. At times, regular passenger operations were even suspended at some airports (Ljubljana, Antalya and Lima). In addition, wide-ranging travel restrictions affected most of the Group airports beginning in the spring.

Traffic at Slovenia's Ljubljana Airport (LJU) fell by 83.3 percent last year to 288,235 passengers (December 2020: down 93.7 percent). The Brazilian airports of Fortaleza (FOR) and Porto Alegre (POA) together received about 6.7 million passengers, representing a 56.7 percent decrease year-on-year (December 2020: down 46.2 percent). Peru's Lima Airport (LIM) reported a 70.3 percent slide in traffic to around 7.0 million passengers (December 2020: down 61.6 percent).

Serving a total of about 8.6 million passengers in 2020, the 14 Greek regional airports experienced a 71.4 percent plunge in traffic (December 2020: down 85.3 percent). Combined traffic at the Twin Star airports of Varna (VAR) and Burgas (BOJ) on the Bulgarian Black Sea coast decreased by 78.9 percent to about 1.0 million passengers (December 2020: down 69.7 percent).

Antalya Airport (AYT) in Turkey registered a 72.6 percent decline in traffic to about 9.7 million passengers (December 2020: down 69.8 percent). Last year, Russia's Pulkovo Airport (LED) in St. Petersburg saw traffic drop by 44.1 percent to about 10.9 million passengers (December 2020: down 38.5 percent). Xi'an Airport (XIY) in China achieved a slight recovery in the course of the year, following a strong reduction in traffic during the spring. In 2020, XIY registered about 31.0 million passengers – a 34.2 percent decrease year-on-year (December 2020: down 14.8 percent).

Print-quality photos of Fraport AG and Frankfurt Airport are available for free downloading via the photo library on the Fraport Web site. For TV news and information broadcasting purposes only, we also offer free footage material for downloading.  If you wish to meet a member of our Media Relations team when at Frankfurt Airport, please do not hesitate to contact us. Our contact details are available here.

 

Fraport AG

Dana Selin Kröll

Telephone: +49 69 690 31403

Corporate Communications

E-mail: [email protected]

Media Relations

Internet: www.fraport.com

60547 Frankfurt, Germany

Facebook: www.facebook.com/FrankfurtAirport

For further information about Fraport AG please click here.

 

 

Fraport Traffic Figures

December 2020

Fraport Group Airports1

December 2020

Year to Date (YTD) 2020

Fraport

Passengers

Cargo*

Movements

Passengers

Cargo

Movements

Fully-consolidated airports

share (%)

Month

Δ %

Month

Δ %

Month

Δ %

YTD

Δ %

YTD

Δ %

YTD

Δ %

FRA

Frankfurt

Germany

100.00

891,794

-81.7

182,568

8.9

13,627

-62.8

18,768,601

-73.4

1,914,285

-8.5

212,235

-58.7

LJU

Ljubljana

Slovenia

100.00

5,422

-93.7

1,143

11.0

686

-61.4

288,235

-83.3

10,559

-7.1

12,980

-58.8

Fraport Brasil

100.00

782,592

-46.2

6,111

-25.1

7,952

-38.3

6,718,048

-56.7

51,528

-39.8

70,809

-48.5

FOR

Fortaleza

Brazil

100.00

361,676

-47.7

3,494

-32.4

3,662

-34.7

3,156,418

-56.3

29,356

-39.3

32,897

-44.9

POA

Porto Alegre

Brazil

100.00

420,916

-44.8

2,617

-12.5

4,290

-41.1

3,561,630

-57.1

22,172

-40.4

37,912

-51.2

LIM

Lima

Peru

80.01

768,959

-61.6

18,422

-28.4

7,673

-54.9

7,017,414

-70.3

190,365

-29.8

73,255

-63.0

Fraport Regional Airports of Greece A+B

73.40

102,623

-85.3

471

-29.9

3,036

-56.2

8,611,780

-71.4

5,330

-29.9

101,007

-58.9

Fraport Regional Airports of Greece A

73.40

69,107

-87.2

400

-28.2

1,894

-59.3

4,838,669

-71.0

4,266

-26.6

54,767

-58.2

CFU

Kerkyra (Corfu)

Greece

73.40

4,826

-78.6

7

-18.7

229

-27.8

961,037

-70.7

72

-59.7

10,889

-57.0

CHQ

Chania (Crete)

Greece

73.40

9,125

-83.6

20

18.7

224

-55.4

703,482

-76.4

180

-52.7

7,392

-63.9

EFL

Kefalonia 

Greece

73.40

992

-72.0

0

0.0

88

-20.0

192,477

-75.1

2

> 100.0

3,184

-56.7

KVA

Kavala 

Greece

73.40

794

-85.3

2

-80.8

30

-74.6

72,674

-77.5

38

-61.8

1,142

-67.0

PVK

Aktion/Preveza

Greece

73.40

176

-52.0

0

n.a.

58

3.6

161,408

-74.2

0

-100.0

2,342

-58.1

SKG

Thessaloniki

Greece

73.40

52,035

-88.4

371

-28.9

1,187

-65.6

2,317,336

-66.4

3,974

-22.8

24,966

-55.2

ZTH

Zakynthos 

Greece

73.40

1,159

-63.7

0

n.a.

78

-22.0

430,255

-76.2

0

-98.4

4,852

-63.2

Fraport Regional Airports of Greece B

73.40

33,516

-78.6

72

-38.2

1,142

-49.7

3,773,111

-72.0

1,064

-40.5

46,240

-59.6

JMK

Mykonos 

Greece

73.40

1,400

-80.6

1

-49.0

56

-60.3

409,060

-73.1

47

-46.9

7,556

-59.8

JSI

Skiathos 

Greece

73.40

416

-61.8

0

n.a.

34

-22.7

88,916

-80.1

0

n.a.

1,600

-61.7

JTR

Santorini (Thira)

Greece

73.40

3,049

-90.4

4

-48.5

120

-73.0

572,963

-75.1

66

-61.2

7,286

-65.8

KGS

Kos 

Greece

73.40

4,577

-75.9

7

-70.0

182

-47.1

800,655

-70.1

162

-50.2

7,994

-59.6

MJT

Mytilene (Lesvos)

Greece

73.40

7,053

-75.0

22

-11.7

234

-48.9

206,095

-58.5

228

-34.6

3,729

-43.2

RHO

Rhodes

Greece

73.40

12,388

-78.2

26

-31.8

330

-39.1

1,551,123

-72.0

377

-39.8

14,801

-60.5

SMI

Samos

Greece

73.40

4,633

-63.2

11

-40.8

186

-37.6

144,299

-69.9

184

-20.5

3,274

-47.8

Fraport Twin Star

60.00

27,948

-69.7

1,015

> 100.0

474

-43.0

1,046,467

-78.9

3,934

-19.2

10,960

-69.1

BOJ

Burgas

Bulgaria

60.00

2,590

-79.0

1,014

> 100.0

94

-39.4

424,252

-85.3

3,889

-18.1

4,079

-79.6

VAR

Varna

Bulgaria

60.00

25,358

-68.3

1

-79.4

380

-43.9

622,215

-70.1

44

-64.1

6,881

-55.5

At equity consolidated airports

AYT

Antalya

Turkey

51.00

263,536

-69.8

n.a.

n.a.

2,473

-61.3

9,713,650

-72.6

n.a.

n.a.

65,223

-68.4

LED

St. Petersburg

Russia

25.00

828,230

-38.5

n.a.

n.a.

8,546

-32.5

10,944,421

-44.1

n.a.

n.a.

105,042

-37.7

XIY

Xi'an

China

24.50

3,212,568

-14.8

42,773

0.9

26,791

-6.4

31,083,681

-34.2

376,320

-1.5

254,607

-26.2

 

 

Frankfurt Airport2

December 2020

Month

Δ %

YTD 2020

Δ %

Passengers

891,925

-81.7

18,770,998

-73.4

Cargo (freight & mail)

185,687

9.0

1,952,628

-8.3

Aircraft movements

13,627

-62.8

212,235

-58.7

MTOW (in metric tons)3

1,100,860

-53.6

14,874,646

-53.3

PAX/PAX-flight4

91.7

-35.6

108.6

-26.0

Seat load factor (%)

51.9

58.4

Punctuality rate (%)

74.1

82.9

Frankfurt Airport

PAX share

Δ %5

PAX share

Δ %5

Regional Split

Month

YTD

Continental

59.5

-81.5

66.2

-72.3

 Germany

8.1

-86.5

10.1

-74.3

 Europe (excl. GER)

51.4

-80.4

56.1

-72.0

  Western Europe

41.8

-80.5

47.1

-71.6

   Eastern Europe

9.6

-79.9

9.0

-73.8

Intercontinental

40.5

-82.0

33.8

-75.3

 Africa

6.7

-76.6

4.9

-72.5

 Middle East

7.3

-77.9

5.5

-71.8

 North America

12.5

-83.6

10.6

-78.1

 Central & South Amer.

6.3

-75.9

4.4

-65.6

 Far East

7.7

-87.4

8.3

-78.2

 Australia

0.0

n.a.

0.1

n.a.

 

Definitions:1 According to ACI definition: Passengers: commercial traffic only (arr+dep+transit counted once), Cargo: commercial and non-commercial traffic (arr+dep excluding transit, in metric tons), Movements: commerical and non-commercial traffic (arr+dep), preliminary figures; 2Commercial and non-commercial traffic: Passengers (arr+dep+transit counted once, incl. general aviation), Cargo (arr+dep+transit counted once, in metric tons), Movements (arr+dep); 3Inbound traffic only; 4  Scheduled and charter traffic; 5absolute change vs. previous year in % ; *Cargo =Freight + mail

 

 

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42Gears SureMDM Simplifies Setting up Kiosk Mode on Linux Devices

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BANGALORE, India, Jan. 18, 2021 /PRNewswire/ — 42Gears today announced its capability to enable kiosk mode on Linux devices using the 42Gears mobile device management (MDM) solution, SureMDM. 42Gears SureMDM is now capable of managing, monitoring, and securing Linux, Android, iOS, iPadOS, and Windows devices from a single pane of glass.

42Gears Mobility Systems Logo

Although Linux already had a kernel lockdown feature that prevented developers from modifying the kernel in any way, businesses still needed a mechanism that could help them convert Linux devices into dedicated purpose tools if required. However, MDM solutions capable of locking down Android, iOS, iPad OS, and Windows devices lacked the capability to lockdown Linux devices. Thus, until now, businesses using Linux devices along with devices based on other operating systems had to use two separate platforms to enable kiosk mode on their enterprise devices.

“It's both effort- and cost-intensive for businesses to use a different solution to enable kiosk mode on Linux devices. This is the problem Linux Profiles addresses – it helps businesses restrict user access to approved apps and settings only using SureMDM, which is already capable of enabling kiosk mode on non-Linux devices,” said Prakash Gupta, CTO and co-founder of 42Gears. “This naturally means that businesses will no longer need two different solutions to manage Linux as well as other platforms. This will certainly have a positive impact on the total cost of ownership, while easing device management even further.”

Apart from enabling kiosk mode on Linux devices, Linux Profiles can also help businesses in:

  • User Management – IT admins can add or remove users, grant or revoke admin access, and allow users to access machines during specific windows of time
  • Wi-Fi Configuration – It is now possible for IT admins to remotely configure Linux devices with wireless network credentials
  • System Settings – This feature will allow IT admins to remotely control peripherals, install or update packages, and modify settings for Wi-Fi, Clipboard, and more
  • URL Blocking – IT admins can now block access to specific URLs on remote machines

Linux Profiles is already available for use by 42Gears customers ready to manage their Linux devices through SureMDM. Please email [email protected] with any inquiries. To learn more, visit the 42Gears Linux web page.

About 42Gears

42Gears is a leading Unified Endpoint Management solution provider, offering SaaS and on-premise solutions to secure, monitor, and manage all business endpoints, such as tablets, phones, desktops, and wearables. 42Gears products support company-owned as well as employee-owned devices built on Android, iOS, iPadOS, Windows, macOS, Wear OS, VR, and Linux platforms. 42Gears products are used in various industries, such as healthcare, manufacturing, logistics, education, and retail. 42Gears products are trusted by over 10,000 customers in more than 115 countries. For more information, please visit https://www.42gears.com.

Logo: https://mma.prnewswire.com/media/517153/42Gears_Mobility_Systems_Logo.jpg

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DIT Group grew rapidly in 2020 with 72% increase in sales volume

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Speeding Up Business Expansion Nationwide by Signing Several Strategic Cooperation Agreements and Collaborating with CCRE Group

 

HONG KONG SAR – Media OutReach – 6 January 2021 – DIT Group Limited (“DIT” or the “Company” which together with its subsidiaries is referred to as the “Group”, SEHK stock code: 726), an innovative high-tech company specializing in businesses in the whole value chain of prefabricated construction in the People’s Republic of China (“PRC”), grew rapidly in 2020 in terms of operating results: its full-year production volume increased by 66% and sales volume rose by 72%. The rapid growth in the Group’s business scale was mainly attributable to strong market demand driven by Chinese government’s policies on fostering the country’s prefabricated construction industry. The growth was also due to the Group’s successful establishment of five green construction industrial parks during the year, including those in Dengfeng City, Zhumadian City, Luoyang City and Tongxu County in Henan Province, and Ding’an County in Hainan Province, and the completion and the launch of six green construction industrial parks in Zhoukou City and Tongxu County in Henan Province, Jiaozhou City in Shandong Province, Huai’an City and Nantong City in Jiangsu Province and Yuxi City in Yunnan Province.

 

The Group signed strategic cooperation agreements with a number of renowned enterprises in 2020, including JD.com Group, Jinke Property Group, Sunriver Holdings Group and Jujiang Construction Group, etc. The collaborations with the well-established companies have resulted in synergies which allow DIT Group to further expand its business and build up its business presence nationwide. This has also enhanced the Group’s capabilities of running businesses across the whole value chain of prefabricated construction and provided a stable source of orders for this year.

 

In July 2020, Mr. Wu Po Sum, the controlling shareholder of the Group, increased his shareholding in the Company for a consideration of approximately HK$303 million; in December 2020, Mr. Liu Weixing, the chairman of the board of directors and executive director of the Group, and Mr. Guo Weiqiang, the chief executive officer and executive director of the Group, increased their shareholdings in the Company for a total consideration of over HK$1.6 million. These moves reflected the confidence of the major shareholder and senior management in the prospects of the Group’s future development and its enterprise value. In addition, the Group adopted a stock option scheme in July 2020, under which a total of approximately 202 million stock options were granted to senior executives. This arrangement will bind together the interests of the employees and those of the Company and its shareholders tightly as it motivates the grantees to be more proactive at work, and can effectively retain and motivate the key talents, thereby promoting the long-term, steady development of DIT Group.

DIT Group is committed to becoming a leading solution provider for smart buildings. In 2020, the Group announced its new “Intelligent Construction of Home” strategy, which aims at creating an innovative model of running businesses in the whole value chain of prefabricated industry with synergy. The Group devotes itself to technological innovation along the whole value chain in such businesses as construction of smart residential buildings and promoting the development of the prefabricated construction industry. Meanwhile, the Group plans to set up a new business model for the whole value chain of the industry by developing a “turnkey” business model that encompasses design, intelligent prefabricated construction, landscaping service and interior decoration in the entire life cycle of a prefabricated construction project.

 

DIT Group’s chief executive officer and executive director Guo Weiqiang said, “DIT Group has been forging ahead with its business development and growing rapidly since it joined the family of the CCRE Group. It has been producing encouraging results. The Group will draw on the technological advantage afforded by the operation of businesses that span the whole value chain of prefabricated construction and will continue to collaborate with the CCRE Group to build its footholds across China more quickly. It will also actively develop new projects to explore the blue ocean in the market for prefabricated construction. Now that the state has adopted a policy on fostering the prefabricated construction industry, the Group is confident about its prospect and plans to expand its share of China’s market rapidly in three to five years. It will also commit itself to enabling consumers to enjoy a safer, comfortable life at smart residential buildings and contributing to China’s new type of urbanization and the modernization of the country’s construction industry.”

About DIT Group Limited

Headquartered in Changsha and Zhengzhou China, DIT Group Limited is an innovative high-tech enterprise that specializes in businesses throughout the entire value chain of prefabricated construction (PC). The company is listed on the main board of the Stock Exchange of Hong Kong Limited (stock code: 726.HK), and is also the first listed company in China’s PC industry.

 

The Group promotes the modernization of construction industry, and its businesses cover the entire value chain of the PC industry, including R&D, PC components manufacturing, franchise and consultation of PC plants, and manufacturing of intelligent PC equipment. The Group has already set up several smart PC equipment plants nationwide. It runs fifteen self-operated PC plants and several plants owned and operated by franchisees. 

 

By adopting the world’s first business model of combining engineering, manufacture, procurement and construction (EMPC), which is created by Drawin Group, DIT Group has been widely recognized by its clients for its technology and products. DIT Group has green construction industrial parks in over 45 cities in 22 provinces nationwide, providing service for projects under construction with a total site area of 6 million square meters in China.

 

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Hit the record for the longest maturity period and the lowest coupon rate of the Group’s offshore bond issuance Optimize the...

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The Innovation of LikeLib 2.0 Redefines Public Chain Technology

MINSK, REPUBLIC OF BELARUS – Media OutReach – 6 January 2021 – LikeLib is a community-based open source blockchain project that uses blockchain technology...

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DIT Group grew rapidly in 2020 with 72% increase in sales volume

Speeding Up Business Expansion Nationwide by Signing Several Strategic Cooperation Agreements and Collaborating with CCRE Group   HONG KONG SAR – Media...

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Burkhard Eling takes up role of CEO at Dachser

The next generation has arrived: A new Executive Board team for the new year   KEMPTEN / HONG KONG –...

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Management Development Institute of Singapore (MDIS) facilitates upskilling & reskilling with online MBAs & courses

SINGAPORE – Media OutReach – 5 January 2021 – As we to move into Phase 3 of Covid-19 towards the end...