Navitor Pharmaceuticals, Inc., the leader in the development of mTORC1-targeted therapeutics designed to help patients live longer and healthier lives, announced today the publication of a peer-reviewed article in the Nature journal Scientific Reports, detailing the discovery and characterization of NV-5138 as a potential therapy for treatment-resistant depression (TRD). NV-5138 is a first-in-class, orally-active small molecule that directly activates mTORC1, the gatekeeper of cellular metabolism and renewal, which is suppressed in the brain of people suffering from depression. NV-5138 is currently in Phase 1 development for the treatment of TRD, with top-line results expected in mid-2019.
The pharmacological modulation of the mTOR pathway holds promise in a wide range of therapeutic indications but to date, has almost exclusively centered on inhibitors. We have identified a novel, highly selective, orally bioavailable compound that activates mTORC1 in the brain. To our knowledge, this is the first selective mTORC1 activator targeting an amino acid sensor that is brain penetrant and achieves significant mTORC1 activation, said George P. Vlasuk, Ph.D., President and Chief Scientific Officer of Navitor.
Navitors scientific founder, David M. Sabatini, M.D., Ph.D., Professor of Biology at the Massachusetts Institute of Technology, Member of Whitehead Institute for Biomedical Research, and Investigator of the Howard Hughes Medical Institute, discovered and characterized sestrin1 and 2 proteins (sestrin), which function as cellular sensors for the amino acid leucine, a natural activator of the mTORC1 pathway. NV-5138 was designed by Navitor to specifically bind to sestrin and activate mTORC1. Unlike leucine, however, NV-5138 is able to effectively activate mTORC1 in the brain, which makes it uniquely suited to target disorders of the CNS where there is reduced mTORC1 pathway activity.
Dr. Sabatini commented, Translating the basic biological discoveries from my laboratory into practical opportunities to discover promising therapeutics is immensely gratifying. By mimicking the binding of leucine to sestrin to specifically activate mTORC1, NV-5138 provides validation for the rational targeting of key regulatory pathways upstream of mTORC1, an approach that offers the potential to unlock the full therapeutic potential of the mTOR pathway.
The article, title Discovery of NV-5138, the first selective Brain mTORC1 activator is published in the latest edition of the peer-reviewed journal Scientific Reports, an online, open access journal from the publishers of Nature, which publishes scientifically valid primary research from all areas of the natural and clinical sciences. The paper can be found at www.nature.com/articles/s41598-019-40693-5.
NV-5138 is an orally bioavailable, small molecule that directly and transiently activates mTORC1, the master modulator of cellular metabolism, which is often suppressed in the brain of patients suffering from depression. NV-5138 binds to and modulates sestrin, a newly discovered cellular sensor protein for the amino acid leucine, a potent natural activator of mTORC1. As opposed to many other organ systems like skeletal muscle, leucine is a poor activator of mTORC1 in the brain since it is principally used as a metabolic precursor for neurotransmitter and protein synthesis. NV-5138 was designed to avoid the metabolic fate of leucine in the brain and thus serves as an effective activator of mTORC1 in this tissue. Results from preclinical models demonstrate that oral administration of NV-5138 produces rapid upregulation of key synaptic proteins, synaptic remodeling in the prefrontal cortex and hippocampus, sustained antidepressant behavioral responses, cognitive improvements and compound-specific spectral power changes, as measured by quantitative electroencephalography (qEEG). Navitors strong intellectual property portfolio includes composition of matter patent protection for NV-5138 and related compounds.
mTORC1, or Complex 1 of the mechanistic target of rapamycin, activity governs the pace and ability of the cell to synthesize protein and other cellular components. Increased mTORC1 activity contributes to a broad array of diseases of aging by increasing protein misfolding and driving cellular stress, inflammation, and fibrosis. In other disease states such as severe depression, inadequate mTORC1 activity contributes to disease pathology by limiting energy utilization and protein synthesis, leading to impaired function. Multiple preclinical studies have shown that mTORC1 activation is required for the efficacy of many rapid-acting antidepressant compounds, including but not limited to modulators of the N-methyl-D-aspartic-acid (NMDA)-mediated signaling pathway like ketamine.1
Navitor Pharmaceuticals, Inc. is the leader in the development of mTORC1-targeted therapeutics designed to help patients live longer and healthier lives. The Companys proprietary platform enables true modulation of mTORC1, the gatekeeper of cellular metabolism and renewal, with the first-ever absolutely selective mTORC1 inhibition and the unique ability for mTORC1 activation. Navitors lead clinical-stage candidate, NV-5138, is a small molecule that directly activates mTORC1 and is being developed for treatment-resistant depression, with additional opportunities in cognition and memory. The Companys NÎ›Valog program, which provides unprecedented selectivity in mTORC1 inhibition, is initially targeting chronic kidney disease and has broad potential application for age-related diseases. For more information, please visit www.navitorpharma.com.
1. Zanos, P. et al., CNS Drugs. 2018; 32(3): 197-227