Connect with us

News

iosBio signs exclusive worldwide licensing agreement granting ImmunityBio rights to OraPro™ oral vaccine platform technology for COVID-19  

gbafNews28

PRESS RELEASE

iosBio signs exclusive worldwide licensing agreement granting ImmunityBio rights to OraPro™ oral vaccine platform technology for COVID-19             

  • iosBio licenses its OraProTM thermal stabilization technology to ImmunityBio for oral delivery of ImmunityBio’s second generation hAd5 vaccine candidate to protect against COVID-19
  • ImmunityBio’s oral T cell vaccine candidate could potentially address mutations in the spike (S) protein

Burgess Hill, UK, January 12, 2021—iosBio (‘the Company’), a UK-based biotechnology company developing next-generation vaccines that can be administered orally, today announced an exclusive worldwide licensing agreement with ImmunityBio, Inc. a US-based, privately-held clinical-stage immunotherapy company, for iosBio’s OraPro™ vaccine platform technology currently being investigated in trials of ImmunityBio’s second-generation human Adeno (hAd5) COVID-19 vaccine candidate.

OraPro™ is iosBio’s patented oral delivery vaccine platform technology that enables oral administration of thermally-stable, viral vector vaccines. These vaccine vectors are engineered to withstand temperatures of up to 50°C, allowing them to pass through the hostile conditions in the stomach without loss of efficacy and providing long-term product stability at ambient temperatures. Oral administration delivers the vaccine directly to mucosal associated lymphoid tissue (MALT), generating mucosal, systemic and T-cell immune responses.

Under the terms of the licensing agreement, iosBio has granted ImmunityBio exclusive rights to utilize its OraPro™ platform technology for the oral delivery of ImmunityBio’s human Adeno (hAd5) COVID-19 vaccine candidate.

iosBio will be eligible to receive royalties on net worldwide sales of the approved oral vaccine.

In a BARDA-sponsored study of vaccinated non-human primates, subcutaneous and room temperature oral formulations of ImmunityBio’s vaccine candidate inhibited SARS-CoV-2 virus replication to undetectable levels and cleared infection within days in 100% of vaccinated animals (10 of 10). The vaccine candidate, which delivers both outer spike (S) and inner nucleocapsid (N) antigens, induced T cells and antibodies leading to reduction of SARS-CoV-2 viruses in both lungs and nasal passages within seven days. The oral capsule formulation of the vaccine candidate was effective at room temperature in the non-human primate study suggesting that it may not require the cold chain logistics that can impede global distribution.

Pending ImmunityBio’s discussions with the US Food and Drug Administration (FDA), the oral vaccine will enter Phase I trials as a prime and boost, and will be explored to provide a boost to subcutaneous vaccinations. Twenty participants have already completed testing in ImmunityBio’s Phase I trial at Hoag Hospital Newport Beach, California, which evaluated both low and high doses of subcutaneous hAd5, with zero grade 3/4 adverse events reported.

Chairman of iosBio, Wayne Channon, said: “We are delighted to be able to support ImmunityBio with the oral delivery of its second-generation COVID-19 vaccine candidate, through the licensing of our OraPro thermal stabilization technology. This technology is key to developing vaccines that can be administered orally without loss of efficacy and has the potential to truly transform vaccine development.

“Oral vaccines have the potential to overcome global challenges of traditional vaccines, many of which need to be stored and transported at freezing temperatures. Oral vaccines are more cost effective to produce and can be easily stored and transported around the world. They also have the potential to be self-administered, reducing health systems’ dependency on trained health professionals to run immunisation programmes and present a future where people could have vaccines delivered straight to their door.”

Patrick Soon-Shiong, M.D., Chairman and CEO of ImmunityBio, said: “As we see multiple mutations in the SARS-CoV-2 spike protein, there is an urgent need for a vaccine that not only offers immediate protection but also activates T cells to clear the virus. When multiple mutations occur at the receptor-binding domain of the spike protein, it renders antibodies ineffective. Our next-generation vaccine design drives both antibody and T cells to S and N protein, and so could potentially serve as a universal boost to current vaccines that focus only on the monovalent S protein, as well as address future mutations of the S protein.

“It is also critical to develop a room-temperature, stable oral formulation of the vaccine, one that will provide mucosal immunity. We’re doing that with iosBio’s unique oral vaccine delivery platform technology that has the potential to transform the way people take vaccines and addresses the challenges of storage and global distribution of vaccines. In our BARDA-sponsored, non-human primate challenge study, administering the oral formulation as a boost achieved 100 percent viral protection against a challenge and induced both memory B cells and Th1-dominant T cells, which cleared the virus. We are now moving urgently through clinical development in the US and globally.”

Ends

For further information please contact:

Consilium Strategic Communications Mary-Jane Elliott, Melissa Gardiner, David Daley, [email protected] Tel: +44 (0) 20 3709 5700

NOTES FOR EDITORS

About iosBio iosBio is a UK based biotechnology company developing next generation vaccines that can be administered orally.

The Company’s proprietary OraPro™ thermal stabilization technology enables the oral administration of thermally stable, non-replicating viral vectors that can be delivered sublingually via the gastrointestinal (GI) tract and other routes. These vaccine vectors are engineered to withstand temperatures of up to 50 degrees, allowing them to pass through the hostile conditions in the stomach without loss of efficacy and providing long term product stability at ambient temperatures.

iosBio is developing vaccines designed to stimulate mucosal, systemic and T cell immune responses, providing robust immunity to a number of infectious diseases including COVID-19, Zika and influenza.

iosBio is headquartered in Burgess Hill, UK. For more information visit: iosbio.com

About ImmunityBio  ImmunityBio, Inc. is a late-clinical-stage immunotherapy company developing next-generation therapies that drive immunogenic mechanisms for defeating cancers and infectious diseases. The company’s immunotherapy platform activates both the innate (natural killer cell and macrophage) and adaptive (T cell) immune systems to create long-term “immunological memory.” This novel approach is designed to eliminate the need for high-dose chemotherapy, improve upon the outcomes of current CAR T-cell therapies, and extend beyond checkpoint inhibitors.

ImmunityBio’s platform is based on the foundation of three separate modalities: antibody cytokine fusion proteins, synthetic immunomodulators, and second-generation human adenovirus (hAd5) vaccine technologies.

Anktiva™ (ImmunityBio’s lead cytokine infusion protein) is a novel interleukin-15 (IL-15) superagonist complex and has received Breakthrough Therapy and Fast Track Designations from the U.S. Food and Drug Administration (FDA) for BCG-unresponsive CIS non-muscle invasive bladder cancer (NMIBC). The company is also in Phase 2 or 3 trials for indications such as first- and second-line lung cancer, triple-negative breast cancer, metastatic pancreatic cancer, recurrent glioblastoma, and soft tissue sarcoma in combination with the company’s synthetic immune modulator (aldoxorubicin).

ImmunityBio is also developing therapies, including vaccines, for the prevention and treatment of HIV, influenza, and the coronavirus SARS-CoV-2 with its second-generation human adenovirus (hAd5) vaccine technologies.

NantKwest Transaction

As previously announced, on December 21, 2020, ImmunityBio entered into an agreement to combine in a stock-for-stock transaction with NantKwest, Inc. (NASDAQ: NK). The combination, which is expected to close in the first half of 2021, would create a leading immunotherapy and cell therapy company focused on oncology and infectious disease.

Primary Logo

News

Transom Consulting Group Announces the Promotion of Paul Yoo to Partner

gbafNews28

LOS ANGELES, Jan. 18, 2021 /PRNewswire/ — Transom Consulting Group, a leading strategy and operational excellence consultancy and investment bank, announced today the promotion of Paul Yoo to Partner.

“We are delighted to announce the promotion of Paul to Partner. Paul has made significant contributions to the breadth and depth of our capabilities and has been a key reason for our growth in the consumer goods and retail sector. His promotion is a recognition of the value he has brought to our clients and our firm. Paul has not only achieved tremendous results for corporate clients, but also for investors in the space,” says David Ascher, founder and Managing Partner of Transom Consulting.

Paul joined Transom in 2019 and leads the firm's Consumer Goods and Retail practice. Prior to joining, Paul served as the CEO of This Saves Lives and as Head of Business Development at The Honest Company. Previously, Paul was a Senior Manager at McKinsey & Company, where he advised Fortune 100 clients on corporate strategy, operations, and M&A strategy.

Paul has an undergraduate degree from Stanford University and a J.D. from Harvard Law School.

About Transom Consulting Group:

Transom Consulting Group provides consulting services focused on strategy and organizational excellence as well as investment banking services in the financial services, consumer goods/retail, and business services sectors. Transom's clients range from high-growth companies to established Fortune 100s and top investment firms. Transom helps clients tackle their most challenging problems by working closely with top executives to develop pragmatic and data-driven recommendations with immediate financial impact. For more information about Transom Consulting Group, visit http://www.transomconsulting.com or contact [email protected].

 

Cision View original content:http://www.prnewswire.com/news-releases/transom-consulting-group-announces-the-promotion-of-paul-yoo-to-partner-301210287.html

SOURCE Transom Consulting Group

Continue Reading

News

Hawaiian Electric Industries To Announce Fourth Quarter And Full Year 2020 Results And 2021 Earnings Guidance Feb. 16; American Savings Bank To Announce 2020 Results Jan. 29

gbafNews28

HONOLULU, Jan. 18, 2021 /PRNewswire/ — Hawaiian Electric Industries, Inc. (HEI) (NYSE: HE) will announce its fourth quarter and full year 2020 financial results Tuesday, February 16. In addition, American Savings Bank, F.S.B. (American), a wholly owned indirect subsidiary of HEI, will announce its fourth quarter and full year 2020 financial results Friday, January 29.

HEI will conduct a webcast and conference call to discuss fourth quarter and full year 2020 earnings, 2021 earnings guidance and regulatory and other matters on Tuesday, February 16 at 11:15 am Hawaii time (4:15 pm Eastern time).

Parties in the U.S. may listen to the conference call by dialing (844) 834-0652.  International parties may listen to the conference call by dialing (412) 317-5198. Parties may also access presentation materials and/or listen to the conference call by visiting the conference call link on HEI's website at www.hei.com under “Investor Relations,” sub-heading “News and Events – Events and Presentations.”

A replay will be available online and via phone. The online replay will be available on HEI's website about two hours after the event. An audio replay will also be available about two hours after the event through March 2, 2021. To access the audio replay, dial (877) 344-7529 (U.S.) or (412) 317-0088 (international) and enter passcode 10151332.

HEI and Hawaiian Electric Company, Inc. (Hawaiian Electric) intend to continue to use HEI's website, www.hei.com, as a means of disclosing additional information; such disclosures will be included in the Investor Relations section of the website. Accordingly, investors should routinely monitor the Investor Relations section of HEI's website, in addition to following HEI's, Hawaiian Electric's and American's press releases, HEI's and Hawaiian Electric's SEC filings and HEI's public conference calls and webcasts.  Investors may sign up to receive e-mail alerts via the “Investor Relations” section of the website. The information on HEI's website is not incorporated by reference into this document or into HEI's and Hawaiian Electric's SEC filings unless, and except to the extent, specifically incorporated by reference.

Investors may also wish to refer to the Public Utilities Commission of the State of Hawaii (PUC) website at dms.puc.hawaii.gov/dms to review documents filed with, and issued by, the PUC. No information on the PUC website is incorporated by reference into this document or into HEI's and Hawaiian Electric's SEC filings.

HEI supplies power to approximately 95% of Hawaii's population through its electric utility, Hawaiian Electric; provides a wide array of banking and other financial services to consumers and businesses through American, one of Hawaii's largest financial institutions; and helps advance Hawaii's clean energy and sustainability goals through investments by its non-regulated subsidiary, Pacific Current.

Contact: Julie Smolinski

Phone:  (808) 543-7300

Vice President, Investor Relations & Corporate Sustainability 

E-mail: [email protected]

 

Hawaiian Electric Industries, Inc. (PRNewsFoto/Hawaiian Electric Industries, Inc.)

 

Cision View original content to download multimedia:http://www.prnewswire.com/news-releases/hawaiian-electric-industries-to-announce-fourth-quarter-and-full-year-2020-results-and-2021-earnings-guidance-feb-16-american-savings-bank-to-announce-2020-results-jan-29-301209825.html

SOURCE Hawaiian Electric Industries, Inc.

Continue Reading

News

Planswell Fills C-Suite with Eye Towards Global Expansion

gbafNews28

Early US success ignites drive to Latin America, Asia    

TORONTO, Jan. 18, 2021 /PRNewswire/ – Planswell,  the Toronto-based startup delivering free financial plans in about three minutes at Planswell.com, is preparing for expansion to Latin America and Asia by filling key executive positions. C-suite hires join Chief Executive Officer Eric Arnold and Chief Operating Officer Scott Wetton to navigate rapid growth for the company.

Planswell entered the US market in October of 2020 with US revenue quickly surpassing business in Canada, the company's home base. To date, over 1000 advisors in North America have partnered with Planswell from virtually every major financial institution— in addition to solo, independent firms—to help consumers action their financial plans. Planswell has delivered over 300,000 free financial plans to households located in every US state and Canadian province.

In preparation for further expansion, Planswell adds Trevor Oseen of Calgary as Chief Financial Officer. Oseen has extensive experience building companies around the world after landing in his first CFO position of a public, internationally traded energy company at 29. He's since worked in eighty countries while finding time to complete  23 marathons and seven Ironman triathlons.

Jennifer Mastrud joins as Chief Marketing Officer after over twenty years of notable marketing leadership experience in diverse sectors ranging from globally syndicated TV to SaaS. She has an impressive track record of turning young startups into industry leaders, building scalable marketing systems, and managing remote teams. Most recently, Mastrud led two-sided national marketing efforts aimed at financial advisors and financial planning clients. Based in the US, Mastrud is a forty-year survivor of Minnesota winters.

Dean Khialani, a Florida-based technology visionary with a Ph.D. in Information Systems, joins as Chief Technology Officer. Specializing in big data, blockchain, machine learning, and artificial intelligence, Khialani has over 20 years of experience turning code into profitable products in C-level roles at startups and large, established corporations alike.

Scott P. Gill, a leading expert on the US financial regulatory environment,  joins as Chief Compliance Officer heading the development of Planswell's US planning engine. Gill brings guru-level knowledge of RIA compliance after advising hundreds of firms throughout fifteen years in the business. Based in North Carolina, Gill is currently completing a doctorate and operates a charitable organization he founded to serve the homeless.

The executive team leads remote staff dispersed across Canada, the United States, the Philippines, Serbia, Turkey, and Nigeria.

“I am so humbled,” said Eric Arnold, Planswell Chief Executive Officer, “This leadership team is much more experienced than me. I'm confident we'll succeed in Latin America and Asia by the end of this year.” 

For information about open positions at Planswell, please visit partners.planswell.com/careers.

About Planswell
Planswell is on a mission to provide the most actionable financial planning experience to everyone, for free. To learn more, visit planswell.com.

Available For Interviews
Eric Arnold, CEO

Cision View original content to download multimedia:http://www.prnewswire.com/news-releases/planswell-fills-c-suite-with-eye-towards-global-expansion-301210333.html

SOURCE Planswell

Continue Reading
Editorial & Advertiser disclosureOur website provides you with information, news, press releases, Opinion and advertorials on various financial products and services. This is not to be considered as financial advice and should be considered only for information purposes. We cannot guarantee the accuracy or applicability of any information provided with respect to your individual or personal circumstances. Please seek Professional advice from a qualified professional before making any financial decisions. We link to various third party websites, affiliate sales networks, and may link to our advertising partners websites. Though we are tied up with various advertising and affiliate networks, this does not affect our analysis or opinion. When you view or click on certain links available on our articles, our partners may compensate us for displaying the content to you, or make a purchase or fill a form. This will not incur any additional charges to you. To make things simpler for you to identity or distinguish sponsored articles or links, you may consider all articles or links hosted on our site as a partner endorsed link.

Call for Entries

Global Banking and Finance Review Awards Nominations 2021
2021 Awards now open. Click Here to Nominate

Latest Posts

gbafNews28 gbafNews28
News53 mins ago

Alera Group Acquires CSNW Benefits

DEERFIELD, Ill. and PORTLAND, Ore., Jan. 18, 2021 /PRNewswire-PRWeb/ — Alera Group, a leading national insurance and financial services firm, today...

gbafNews28 gbafNews28
News53 mins ago

Summit Hotel Properties Announces Fourth Quarter And Full Year 2020 Earnings Release Date

AUSTIN, Texas, Jan. 18, 2021 /PRNewswire/ — Summit Hotel Properties, Inc. (NYSE: INN) (the “Company”) today announced that it will...

gbafNews28 gbafNews28
News53 mins ago

Planswell Fills C-Suite with Eye Towards Global Expansion

Early US success ignites drive to Latin America, Asia     TORONTO, Jan. 18, 2021 /PRNewswire/ – Planswell,  the Toronto-based startup...

gbafNews28 gbafNews28
News53 mins ago

Hawaiian Electric Industries To Announce Fourth Quarter And Full Year 2020 Results And 2021 Earnings Guidance Feb. 16; American Savings Bank To Announce 2020 Results Jan. 29

HONOLULU, Jan. 18, 2021 /PRNewswire/ — Hawaiian Electric Industries, Inc. (HEI) (NYSE: HE) will announce its fourth quarter and full...

gbafNews28 gbafNews28
News53 mins ago

Transom Consulting Group Announces the Promotion of Paul Yoo to Partner

LOS ANGELES, Jan. 18, 2021 /PRNewswire/ — Transom Consulting Group, a leading strategy and operational excellence consultancy and investment bank, announced...

gbafNews28 gbafNews28
News1 hour ago

Suncity Group Announces 2021 Outlook

Striding Towards a Bright Future   MACAU – Media OutReach – 5 January 2021 – Under the impact of the COVID-19 pandemic, 2020...

gbafNews28 gbafNews28
News1 hour ago

“MeCan Trade” – the 1st Social Commerce – Launched To Help Malaysians Trade Across Borders Without Capital Nor Risk

KUALA LUMPUR, MALAYSIA – Media OutReach – 13 January 2021 – Into a new year, the Covid 19 pandemic continues to impact lives...

gbafNews28 gbafNews28
News1 hour ago

Employment in Taiwan Gains Optimism in 2021 Driven By Growth in Sustainable Energy

TAIPEI, TAIWAN – Media OutReach – 13 January 2021 – Professional recruitment services firm Michael Page Taiwan today launched the...

gbafNews28 gbafNews28
News1 hour ago

Give Gift Boutique Predicts A Sales Boom of Preserved Flowers on Valentine’s Day Due to The Growing Demand of Floral Gifts During COVID-19

HONG KONG SAR – Media OutReach – 13 January 2021 – The coronavirus pandemic has taken a sharp toll on stores, and online buying...

gbafNews28 gbafNews28
News1 hour ago

South Korean Startup bitsensing Introduces the Smallest Radar for a Health Monitoring System at CES 2021

The mini Healthcare Radar, mini-H, Creates a Safer and More Convenient Monitoring System for Telehealth   LAS VEGAS, NV – Media...