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Cullgen Announces “Featured Article” Publication of First in Class TRK Protein Degraders in Journal of Medicinal Chemistry

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Cullgen Inc., a leading biotechnology company developing small molecule therapeutics based on its proprietary uSMITE„¢ platform of targeted protein degradation technology, today announced that the companys internal program to develop selective degraders that target key proteins within the TRK family has been published by the Journal of Medicinal Chemistry. The paper, entitled Discovery of First-in-class Potent and Selective Tropomyosin Receptor Kinase Degraders, has been selected as a Featured Article by the editors of the journal based on the novelty and scientific merit of the work.

TRK fusion proteins have been found across a wide range of human malignancies, including lung cancer, colorectal cancer, and soft tissue sarcoma. In addition, TRK fusions appear to be the primary oncological drivers of some rare cancers, such as infantile fibrosarcoma, secretory breast carcinoma, and mammary analogue secretory carcinoma (MASC). The first-in-class degraders developed by Cullgen efficiently degrade mutated, disease causing forms of the TRK protein and subsequently inhibit cancer cell growth. Existing therapies to treat TRK fusions have elicited modest on-target adverse effects, including dizziness and weight gain. In addition, acquired drug resistance has been reported in patients after treatment with approved TRK protein inhibitors. Hence, Cullgens TRK degraders could offer patients a new therapeutic approach to treat TRK-mediated cancer diseases with reduced drug resistance.

We are honored that the Journal of Medicinal Chemistry has selected our publication as a Featured Article. Our tireless team has significantly advanced our TRK degrader program over the past year and we are now rapidly completing IND-enabling studies for our clinical candidate stated Dr. Yue Xiong, co-founder and Chief Scientific Officer of Cullgen. In addition to our TRK program, we are also advancing multiple additional cancer degrader programs through pre-clinical studies, as well as utilizing our uSMITE„¢ platform to discover novel E3 ligands which we are using to develop completely new classes of targeted protein degraders.

Journal of Medicinal Chemistry is a peer-reviewed science and medical journal published by a division of the American Chemical Society (ACS). The journal publishes innovative studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

About Cullgen Inc.

Cullgen is a privately held biopharmaceutical company dedicated to the development of first-in-class new chemical entities (NCEs) for the treatment of diseases lacking effective therapeutic approaches. We are developing our proprietary technology platform, ubiquitin-mediated, small molecule-induced target elimination technology, (uSMITE„¢), based on recent advances in the science of protein degradation. Typically, drugs are designed to interact with the functional sites of proteins and block their activities. We are developing uSMITE„¢ to expand the drug design paradigm beyond functional site inhibition, to make it possible to eliminate previously undruggable enzymes and proteins by targeted destruction. We also intend to use the uSMITE„¢ technology to harness the ubiquitin proteasome system, a multi-step biochemical process that controls protein degradation in all cells. From years of research on the proteasome system and key discoveries about its assembly, Cullgens founders have already demonstrated that the underlying technology can rapidly generate a large number of highly potent, selective, and bioavailable compounds. Furthermore, this process is significantly more cost effective compared with traditional drug discovery approaches. For more information, visit www.cullgen.com.

Cullgen Inc.

Thomas Eastling

[email protected]

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Sinic Holdings Assigned ‘BB-‘ with a Positive Outlook by Lianhe Global

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HONG KONG, Oct. 23, 2020 /PRNewswire/ — Sinic Holdings (Group) Company Limited ("Sinic Holdings" or the "Company", together with its subsidiaries, the "Group", stock code: 2103.HK) announces that Lianhe Ratings Global Limited ("Lianhe Global") has assigned the Company a global scale Long-term Issuer Credit Rating of ‘BB-‘ with a Positive Outlook.

Lianhe Global believed that Sinic’s management expects to further grow its scale by deepening the city coverage and expanding into new regions through the twelve regional offices/teams. Sinic uses cash received from its project development to partly fund the growth plan of its market franchise into the provincial cities in the Yangtze River Delta, Greater Bay Area, and Central and West China Region of higher potential. Sinic managed the average time required before presale for high-turnover projects down to about six months in 2019 from approximately eight months in 2018. The change sheds light on the results of its internal benchmarks and indicators that Sinic employed to monitor the status of each development phase.

The Shanghai headquartered developer redesigned the product type by series and modularized its development approach to shorten the average construction duration, which lowered the operating costs and paved the way for its ambitious expansion. More than 90% of Sinic’s high-turnover projects under development at end-2019 were on the new standardized model, somewhat expediting the completion of certain projects.

Lianhe Global expected Sinic to moderately improve its tight liquidity profile with various funding sources – including bank loans, trust loans, bond offerings, and other financing tools such as ABS products, etc. – to fund its expansion blueprint. Sinic is able to tap the onshore fixed-income market. Listed on the Hong Kong Stock Exchange since November 2019, the Company has gained access to the offshore capital market, which further diversified its funding source.

The Chairman and Executive Director of Sinic Holdings, Mr. Zhang Yuanlin said, "The ‘BB-‘ Rating with a Positive Outlook assigned by Lianhe Global is evidence of our long-term investment value, and highlights the recognition of the rating agency of the Company’s performance, stable financial position and high-quality development model. It will also be conducive to the financing of Sinic Holdings in the capital market at a lower cost in the future. Looking forward, in terms of sales, we will adopt a more active and agile product sales and pricing strategy in response to the market change. In terms of operations, we will adjust the delivery cycle in a timely manner according to market demand. In terms of finance, we will carry out a more prudent financial policy and strengthen cash flow management with an aim of securing steady development with a healthy financial condition. Sinic Holdings will consolidate its current market position and further accelerate development of its business, striving to achieve the strategic development of ‘laying a solid foothold in Jiangxi for nationwide development."

About Sinic Holdings (Group) Company Limited

Sinic Holdings (Group) Company Limited is a large-scale and comprehensive property developer in the PRC, focusing on the development of residential and commercial properties. Through over 10 years of operations, the Company has successfully established a leading position among residential property developers in Jiangxi Province and expanded its property development business into the Yangtze River Delta Region, the Greater Bay Region and the Central and Western China Core Cities and other regions with high-growth potential. According to the rankings of CRIC, China Index Academy and EH Consulting, the Company ranked 36th, 32nd, and 31st in terms of sales amount (including all income) among real estate development enterprises of China in 2019. The Company was recognized as one of the China’s Top 50 Real Estate Developers jointly by the China Real Estate Industry Association, Shanghai Yiju Real Estate Research Institution and China Real Estate Appraisal in 2018 and 2019, and one of the China’s Top 30 Real Estate Developers in 2020 and Growth Top 10 in 2020 by the China Real Estate Top 10 Research Committee and China Index Academy in 2020.

The Company residential properties can be categorized into three major series, namely, the "Wan" Series, the "Yuan" Series and the "Yue" Series, which target first-time home purchasers, home upgraders and extended families or high-income households, respectively. As of June 30, 2020, the total land bank attributable to the Company amounted to approximately 15.3 million sq.m., and the Company had 138 projects at various stages of development.

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Laiye and RAAS PAL Form Partnership to Drive the Industry-wide Automation

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BANGKOK, Oct. 23, 2020 /PRNewswire/ — Laiye, the leading Robotic Process Automation (RPA) platform provider in Asia, and RAAS PAL, a robotics and AIoT solution provider in Thailand, announced the partnership to provide the industry-wide high-quality automation services in Thailand.

Laiye initially delivered some significant projects including Automated Human Resources Outsourcing (HRO) and built the Virtual Office to drive brand engagement and boost RAAS PAL’s productivity.

Technology is completely changing the way we work. In the newly completed projects, Laiye not only automated parts of RAAS PAL’s online recruitment processes but also delivered a virtual office solution that includes many robot employees performing different tasks, like Human Resources Outsourcing, Financial Services Outsourcing, etc. Laiye aims to drive the promise of the fully automated enterprise for the most strategic companies.

"This first step in the adoption of RPA in our group processes has been extremely meaningful for us. We particularly liked the fact that we could start from small to scale. Besides the short learning curve, what touches us even more was Laiye UiBot’s services," said CEO of RAAS PAL. 

This cooperation is expected to deliver automation value to clients of all industries, with those in regulated industries such as finance, banking, manufacturing, human resource, healthcare and more. Furthermore, entrepreneurs see a lot of potential in automating the processes which bring innovative benefits to various aspects of enterprise business.

About Laiye

Founded in 2015, Laiye is a forward-looking company focused on offering automation solutions to a wide range of users from individuals to enterprises. Laiye is a pioneering company in Robotic Process Automation (RPA) and artificial intelligence with more than 19-year experience. Laiye’s mission is to automate all rule-based, repetitive, high-volume digital tasks for you and your business to increase creativity and productivity.

Additional Resources
Follow Laiye on LinkedIn, Facebook, and Twitter, or contact the team at [email protected].

 

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Amcor to report First Quarter 2021 Results

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ZURICH, Switzerland, Oct. 23, 2020 /PRNewswire/ — Amcor plc (NYSE: AMCR; ASX: AMC) will announce its First Quarter 2021 results for the three months ended 30 September 2020 after the US market closes on Thursday 5 November 2020.  

A conference call and webcast to discuss the results will be held at 5.00 pm US Eastern Standard Time on Thursday 5 November 2020 / 9.00 am Australian Eastern Daylight Time on Friday 6 November 2020. For those wishing to participate in the call please use the following dial-in numbers:

US and Canada:

866 211 4133 (toll-free)

Australia:  

1800 287 011 (toll-free)

United Kingdom:

0800 051 7107 (toll-free)

Hong Kong: 

800 901 563 (toll-free)

Singapore:

800 852 6506 (toll-free)

All other countries:

+1 647 689 6614 (this is not a toll-free number)

Conference ID

3965578

Access to the webcast and supporting materials will be available via the Investors section of Amcor’s website (www.amcor.com/investors). A webcast replay will be available at the conclusion of the call.  

In line with Amcor’s reporting obligations, a Quarterly Report on Form 10-Q will be filed with the SEC by Monday 9 November 2020.

ENDS

For further information please contact:

Investors:

Tracey Whitehead

Damien Bird

Head of Investor Relations

Vice President Investor Relations

Amcor

Amcor

+61 3 9226 9028

+61 3 9226 9070

[email protected]

[email protected]  

Media – Europe

Media – Australia

Media – North America

Ernesto Duran

James Strong

Daniel Yunger

Head of Global Communications

Amcor

Citadel-MAGNUS

KekstCNC

+41 78 698 69 40

+61 448 881 174

+1 212 521 4879

[email protected]

[email protected]

[email protected]

 

About Amcor
Amcor is a global leader in developing and producing responsible packaging for food, beverage, pharmaceutical, medical, home- and personal-care, and other products.  Amcor works with leading companies around the world to protect their products and the people who rely on them, differentiate brands, and improve value chains through a range of flexible and rigid packaging, specialty cartons, closures, and services. The company is focused on making packaging that is increasingly light-weighted, recyclable and reusable, and made using a rising amount of recycled content. Around 47,000 Amcor people generate US$12.5 billion in sales from operations that span about 230 locations in 40-plus countries.  NYSE: AMCR; ASX: AMC

www.amcor.com  I  LinkedIn  I  Facebook  I  Twitter  I  YouTube

Related Links :

http://www.amcor.com

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